Probiotics: New microbiological
methods for exceptional quality

Direct, modern microbiology with VIT®: The industrial standard for
Fluorescence in Situ Hybridization (FISH). Identity, purity, stability and
viability analysis directly in the sample.

 

 

 

Why do we need new microbiological methods?

The development and manufacturing of probiotics requires profound microbiological understanding of the relationship and interactions between the selected microorganisms as well as with the host microbiome ecosystem. However, there are certain obstacles and limitations of conventional and novel microbiological methods, like next generation sequencing (NGS) and flow cytometry, that researchers have to overcome in order to gain the required knowledge.

 

Why VIT® and vermicon?

VIT® is a molecular technique which uses specifically programmed fluorescent labelled probes (single strand of DNA that is complementary to a microbial rRNA region of interest). The analysis is performed via fluorescence microscopy or flow cytometry (Flow VIT®). VIT® and Flow VIT® can specifically identify multiple bacteria populations in the same sample, distinguish between live, damaged and dead cells and are cultivation independent. Our mission is to dissolve the methodological limitations and enable the development and production of exceptional probiotics. Using VIT® makes that possible.

Cultivation-free

  • Direct and rapid microbiology.
  • Patented FISH technologies, recognized by the European Pharmacopoeia.
  • GMP certified analysis methods.

Spatial analysis

  • Visualization directly in the sample
  • Specific identification of multiple bacteria species
  • Gives insights into the microbe-to-microbe interactions

Customized solutions

  • Individual solutions and test kit development.
  • Broad technology portfolio.
  • Process optimization.

Improved quality

  • Deeper understanding of the microbe-to-microbe interactions
  • Viability, activity and stability validation of multiple species.

Our services

We work in trustful collaboration with our clients. Our service portfolio offers a broad range of possibilities. The standard services cover a large proportion of analyses relevant for the whole probiotics‘ production process - from research & develompent till end product quality control. In case an individualized solution is needed, we will be happy to consult you.

Microbiome analytics are a highly sensitive area. In order to provide our customers with maximum safety, we are certifying our services according to the GMP (Good Manufacturing Practice) and ISO9001: 2015 standards.

 

  • spatial analysis, identification and visualization

  • viability, activity and safety analysis

  • validation of stability and viability throughout shelf life

  • enumeration

  • composition validation of end products

  • microbial quality monitoring

  • control of contaminants

If you need further assistance or have any questions related to our services and detection methods, please do not hesitate to contact our team of experts. We will be pleased to help you.

Sample types and industries

Probiotic Sample Types

  • raw materials
  • solid and liquid samples
  • single strain & multi species probiotic formulations
  • in vivo and in vitro assays

Probiotic Industries

  • drugs
  • dietary supplements
  • functional & fermented foods
  • feed mills & livestock breeding

Unique Advantages

We start where conventional methods and approaches fail. With our experience, gathered in more than 25 years in the analysis of biocenoses, we answer even highly complex, interdisciplinary microbiological questions.

 

  • cultivation-independent methods

  • enumeration of viable aerobic & anaerobic bacteria

  • pioneers in the application of FISH (VIT®) and Flow FISH (Flow VIT®) for the industrial microbiology

  • highly-qualified experts with decades of experience in applied microbiology

  • innovative and experimental approach

  • customer focused and solution driven

Our customers

[…]


„The importance of bacteria for our health is becoming increasingly obvious. Probiotic drugs open up new avenues in the fight against civilization diseases such as allergies, respiratory diseases and gastrointestinal diseases. With this in mind, SymbioPharm GmbH is committed to consistently and continuously expanding all activities from research to the finished product, searching for new ways and finding unusual treatments.

For more than two decades, vermicon AG has been our accompanying, reliable partner in the research development and quality assurance of our products. With their innovative methods, microbiological know-how and professional way of working, we have found exactly the partner that complements us. The fast exchange with our direct contact person and the entire team in mutual trust is the guarantee for an uncomplicated and successful cooperation.“

Dr. Kurt Zimmermann, Chief Scientific Officer (CSO), SymbioPharm GmbH

Microbiome research

Microbiome research

The human microbiome is a highly complex ecosystem. Products based on living microorganisms generally don’t work in a direct way, but interact in a multifactorial mode of action.

Live Biotherapeutics

Live Biotherapeutics

To ensure the efficacy and safety of Live Biotherapeutics, a deeper understanding of the relationship between the microbiome and the human health is needed.

Expertise and technology

Expertise and technology

vermicon supports pharmaceutical companies and developers of microbiome-based products whenever a specific microbiological expertise, technological equipment or process optimization is needed.