Breakthrough in the Quality Control of Probiotics
The development of probiotics requires a deep microbiological understanding of the relationships and interactions between the individual microorganisms as well as with the microbiological ecosystem of the host. In addition, the production and quality control of probiotics requires precise cell count and activity determination of the individual bacterial species in probiotic mixtures, including non-cultivable bacteria.
However, conventional (cultivation) and novel microbiological methods (Next Generation Sequencing (NGS) and flow cytometry) face obstacles and limitations that need to be overcome to gain the required insights.
Flow VIT® technology overcomes these limitations and enables the direct and precise quantification of viable cells - quickly, safely and specifically.
Implementation
The implementation of Flow VIT® technology is user-friendly and robust. The test kits are easy to use, can be integrated into everyday laboratory work without any special prior knowledge and are compatible with common flow cytometers. The automated workflow reduces manual effort and minimizes sources of error.
The Following Standard Flow VIT® Test Kits Are Now Available
Flow VIT® Lactobacillus acidophilus
Flow VIT® Lactobacillus fermentum
Flow VIT® Lactobacillus gasseri
Flow VIT® Lactobacillus paracasei
Flow VIT® Lactobacillus plantarum
Flow VIT® Lactobacillus rhamnosus
Flow VIT® Lactobacillus reuteri
Flow VIT® Lactobacillus spp.
Flow VIT® Bifidobacterium breve
Flow VIT® Bifidobacterium bifidum
Flow VIT® Bifidobacterium longum
Flow VIT® Bifidobacterium lactis
Flow VIT® Bifidobacterium spp.
Flow VIT® Streptococcus thermophilus
Consulting and Services
For probiotic products and microbiome analyses, we also offer a comprehensive range of laboratory and service solutions. Our standard services cover a large part of the analyses relevant to the entire probiotic production process – from research and development to quality control of the final product. In addition to the proven Flow VIT® method and the VIT® technology, we employ flow cytometry, RT-qPCR, dPCR, 16S rDNA sequencing, and next-generation sequencing – complemented by customized solutions for precise analyses.
Microbiome analysis is a highly sensitive field. To offer our customers the highest level of safety, our services are certified according to GMP (Good Manufacturing Practice) and ISO9001:2015 standards.
Highly specific and rapid cell quantification of multiple bacterial species in the same sample | |
Analysis of viability and activity | |
Validation of stability and viability throughout the entire shelf life | |
Validation of the composition of final products | |
Monitoring of microbial quality | |
Control of contaminations | |
Spatial analysis, identification and visualization |
If you need further support or have questions about our services and detection methods, please do not hesitate to contact our expert team. We will be happy to assist you.
Why vermicon?
vermicon supports pharmaceutical companies, CDMOs and developers of probiotic products with customized, alternative microbiological methods. Our direct approach enables the identification and visualization of bacteria directly in their natural environment and uncovers mechanisms and correlations that cannot be detected with pure sequence data or conventional cultivation methods. This enables us to deliver meaningful results quickly and efficiently.
State-of-the-Art Technologies
Flow VIT® combines fluorescence in situ hybridization (FISH) with flow cytometry for fast, specific and precise microbiological analysis. This technology ensures the detection of living cells only and enables the identification and quantification of multiple species in mixed cultures.
Versatile Applications
Our technologies are used in probiotics, pharmaceutical and clinical research as well as in the water, wastewater and beverage industries. They provide valuable insights and enable reliable quality control. With advanced solutions, the viability, efficacy and stability of products can be specifically validated.
Proven Expertise
With GMP and ISO 9001:2015 certifications, over 25 years of experience and a strong innovative drive, vermicon AG stands for reliable expertise in microbiome research. Our team of experts accompanies the entire process from development to market launch.